Table 2.
Top 10 upregulated and downregulated proteins in HCT cells.
| HBR vs. HCT | Entry | Protein | Function |
|---|---|---|---|
| Up | XDH | Xanthine dehydrogenase/oxidase | Key enzyme in purine degradation |
| B7Z1X3 | Dynein regulatory complex subunit 4 | Microtubule binding, small GTPase binding | |
| H0Y9Y8 | RUN and FYVE domain-containing protein 1 | Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking | |
| A0A2R8Y734 | Thrombopoietin | Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells | |
| A8MXR8 | PHD finger protein 20-like protein 1 | Regulation of transcription, DNA-templated | |
| H7BXL6 | Otogelin-like protein | Extracellular region | |
| CCKAR | Cholecystokinin receptor type A | Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, and smooth muscle contraction of the gall bladder and stomach. | |
| PRAM | PML-RARA-regulated adapter molecule 1 | Lipid binding, protein kinase binding, and integrin-mediated signaling pathway | |
| FHDC1 | FH2 domain-containing protein 1 | Protein localization to plasma membrane | |
| A0A024RDL0 | DNA-directed RNA polymerase III subunit RPC9 | Microtubule-associated formin which regulates both actin and microtubule dynamics | |
|
| |||
| Down | Q7Z487 | Transforming growth factor beta 1 | DNA-directed 5′-3′RNA polymerase activity and nucleotide binding |
| EPO | Erythropoietin receptor | Growth factor activity | |
| COPB2 | Coatomer subunit beta′ | Receptor for erythropoietin mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade | |
| F5H1U3 | Peptidylprolyl isomerase | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi nonclathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network | |
| A0A2R8YDF7 | Lysine-specific demethylase 4A | FK506 binding | |
| ZN727 | Putative zinc finger protein 727 | Heat shock protein binding | |
| Q8N7A4 | cDNA FLJ25865 cis, clone CBR01927 | Peptidyl-prolyl cis-transisomerase activity | |
| A0A2R8Y6R5 | Caseinolytic peptidase B protein homolog | Histone demethylase that specifically demethylates “Lys-9” and “Lys-36” residues of histone H3, thereby playing a central role in the histone code | |
| F8VSE7 | Transcription factor E2F7 | DNA-binding transcription factor activity, RNA polymerase II-specific | |
| ZN616 | Zinc finger protein 616 | Uncharacterized protein | |
Abbreviations: HCT: HCT parental cells; HBR: butyrate-resistant HCT cells.