Fig. 5. Expression in different brain regions and cell types for the 13 causal proteins shared between the psychiatric and neurodegenerative diseases.

A List of the 13 proteins mutually causal in both the psychiatric and neurodegenerative diseases. B Expression of the 13 shared causal proteins in different brain regions based on human brain gene expression data from the Allen Brain Atlas. Higher Z score (red) indicates higher expression, lower Z score (blue) indicates lower expression in that brain region. C Expression of the 13 shared causal proteins in different cell types based on human single-cell RNA-sequencing data. Whether the gene expression in one particular cell-type differed from its expression in all the other four cell types was determined using the Wilcoxon rank sum test. Significant difference was defined as those with Bonferroni-adjusted p value < 0.05 (adjusted for all 17,775 genes). Only 10 of 13 genes were highly expressed in a particular cell type and depicted here. The other 3 genes were expressed similarly across the different cell types.