Table 2.

RPE directional secretion of proteins encoded by disease genes.

Disease	Protein	A/BL
Mendelian posterior segment disease
Oculocutaneous albinism (OCA)	TYRP1	3.7**
Tay-Sachs	HEXA	3.4***
Stickler syndrome	COL11A1	3.3**
Stickler syndrome	COL9A2	2.4**
Cone-rod dystrophy	CDHR1	2.0**
Retinitis pigmentosa (RP)	SNRNP200	2.0**
Late onset retinal degeneration (LORD)	C1QTNF5	1.0
Doyne honeycomb macular dystrophy	EFEMP1	0.9
Cone-rod dystrophy	ADAM9	0.5**
Microphthalmia; retinal dystrophy, iris coloboma, and comedogenic acne syndrome	RBP4	0.4***
Sorsby macular dystrophy	TIMP3	0.1**
Mendelian anterior segment disease
Congenital cataract	CRYAB	10.2****
Mucopolysaccharidosis type IV (with corneal clouding)	GLB1	7.5***
Primary open angle glaucoma (POAG)	OPTN	5.3**
Congenital Cataract	VIM	4.4***
Corneal dystrophies	TGFBI	3.2*
Amyloidosis, meretoja syndrome; lattice corneal dystrophy	GSN	2.0*
Gaucher disease (with corneal opacities)	GBA	2.0*
Other Mendelian ophthalmic disease
Microphthalmia	ALDH1A3	5.4***
Progressive external ophthalmoplegia	RRM2B	4.8***
Age-related macular degeneration risk loci	C3	1.5*
	FBLN5	1.3
	CFH	1.3
	HTRA1	1.2
	CFI	0.6**
	TIMP3	0.1**

A/BL = apical to basolateral ratio; proteins are listed from highest to lowest A/BL within each category. Bold highlights proteins with more basolateral than apical secretion. P-values were calculated with a two-tailed student’s T-test with a Benjamin-Hochberg adjustment. P-value < 0.05 (*), < 0.01 (**), < 0.001 (***), < 0.0001 (****), or > 0.05 (non-significant, no asterisk).