Table 3.
RPE directional secretion of angiogenic factors.
| Protein | A/BL |
|---|---|
| Positive regulation | |
| CRYAB (crystallin alpha B) | 10.2**** |
| ANXA3 (annexin A3) | 7.7*** |
| ECM1 (extracellular matrix protein 1) | 4.4*** |
| ANGPTL4 (angiopoietin like 4) | 3.5**** |
| ANXA1 (annexin A1) | 3.5*** |
| SERPINE1 (serpin family E member 1) | 3.0** |
| GRN (granulin precursor) | 2.8*** |
| MYDGF (myeloid derived growth factor) | 2.7** |
| SFRP1 (secreted frizzled related protein 1) | 0.8 |
| VEGFA (vascular endothelial growth factor A) | 0.7 |
| CX3CL1 (C-X3-C motif chemokine ligand 1) | 0.4* |
| Negative regulation | |
| PGK1 (phosphoglycerate kinase 1) | 7.1***** |
| TGFBI (transforming growth factor beta induced) | 3.2* |
| SERPINF1 (serpin family F member 1; aka PEDF) | 2.9** |
| COL4A2 (collagen type IV alpha 2 chain) | 2.5*** |
| NAXE (NAD(P)HX epimerase) | 2.1** |
| FN1 (fibronectin 1) | 1.8** |
| THBS1 (thrombospondin 1) | 1.4 |
| PTN (pleiotrophin) | 1.2 |
| TGFB2 (transforming growth factor beta 2) | 0.8 |
| THBS4 (thrombospondin 4) | 0.6* |
| SULF1 (sulfatase 1) | 0.5** |
| RNH1 (ribonuclease/angiogenin inhibitor 1) | 0.2** |
A/BL = apical to basolateral ratio; proteins are listed from highest to lowest A/BL within each category. Bold highlights proteins with more basolateral than apical secretion. P-values were calculated with a two-tailed student’s T-test with a Benjamin-Hochberg adjustment. P-value < 0.05 (*), < 0.01 (**), < 0.001 (***), < 0.0001 (****), or > 0.05 (non-significant, no asterisk).