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. 2021 Sep 7;21(4):681–714. doi: 10.1007/s12311-021-01320-0

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Fig. 3 — Frequency graphs illustrating the characteristics of selected studies. (A) Shows the number of studies that report synaptic dysfunction. (B) Illustrates the number of studies which report ALS/FTD pathology in C9-patients. (C) Shows the number of different animal models used in in vivo experiments. (D) Shows the number of different in vitro models used in the selected studies. (E) illustrates the pathomechanism type assessed in different animal models. (F) Illustrates the number of DPR constructs introduced to different animal models. Abbreviations: DPRs, dipeptide repeat proteins; NMJ, neuromuscular junction; cDNA, circular DNA