Table 2.
Features of newly diagnosed IDH + LrGG. Statistically significant MRSI and volumetric parameters among newly diagnosed patients with IDH+ LrGG; 2HG/tCr was reported regardless of significance for each categorical comparison
| LrGG comparison | Parameter | Patients (n1, n2) | Values median (lower, upper quartile) | p–value | |
|---|---|---|---|---|---|
| T2L vs NAWM | T2L | NAWM | |||
| 2HG+ GABA/tCr | 36, 36 | 0.54 (0.38,0.83) | 0.35 (0.30,0.39) | < 0.001 | |
| Glu/tCr | 37, 37 | 0.95 (0.81,1.06) | 1.06 (0.96,1.18) | < 0.001 | |
| Gln/tCr | 37, 37 | 0.54 (0.47,0.64) | 0.45 (0.40,0.51) | < 0.001 | |
| MI/tCho | 37, 37 | 2.94 (2.60,3.47) | 2.55 (2.40,2.82) | 0.001 | |
| MI/tCr | 37, 37 | 1.44 (1.21,1.69) | 1.03 (0.94,1.09) | < 0.001 | |
| mIG/tCr | 37, 37 | 1.64 (1.33,1.87) | 1.08 (0.99,1.20) | < 0.001 | |
| mIG/tCho | 37, 37 | 3.31 (2.92,3.75) | 2.75 (2.57,3.14) | < 0.001 | |
| tCho/tNAA | 37, 37 | 0.35 (0.29,0.47) | 0.20 (0.18,0.21) | < 0.001 | |
| tCho/tCr | 37, 37 | 0.47 (0.43,0.53) | 0.39 (0.36,0.43) | < 0.001 | |
| tNAA/tCr | 37, 37 | 1.32 (1.02–1.51) | 1.97 (1.88,2.13) | < 0.001 | |
| Grade 2 vs 3 | Grade 2 | Grade 3 | |||
|---|---|---|---|---|---|
| MI/tCho | 24, 13 | 3.12 (2.75,3.72) | 2.73 (2.33,2.98) | < 0.05 | |
| 2HG/tCr | 22, 12 | 0.90 (0.76,1.07) | 0.92 (0.67,1.17) | NS |
| Astro vs Oligo | Astro | Oligo | |||
|---|---|---|---|---|---|
| MI/tCho | 21, 16 | 2.91 (2.53,3.17) | 3.36 (2.72,3.76) | < 0.05 | |
| mIG/tCho | 21, 16 | 3.16 (2.75,3.46) | 3.68 (3.22,4.06) | < 0.05 | |
| 2HG/tCr | 19, 15 | 0.90 (0.65,1.00) | 0.93 (0.81,1.15) | NS | |
| Vol. CNIT2L > 2 (cm3) | 21, 16 | 19.9 (16.2,38.0) | 10.0 (6.2,16.8) | < 0.01 | |
| Vol. T2L, grade 2 (cm3) | 11, 13 | 63.6 (30.1,75.0) | 20.4 (13.9,34.4) | < 0.05 |
| p53+ vs p53− | p53+ | p53– | |||
|---|---|---|---|---|---|
| tCho/tCr | 26, 7 | 0.49 (0.44,0.56) | 0.42 (0.38,0.45) | < 0.05 | |
| MI/tCho | 26, 7 | 2.83 (2.42,3.23) | 3.71 (3.08,3.96) | < 0.05 | |
| mIG/tCho | 26, 7 | 3.14 (2.75,3.64) | 4.00 (3.48,4.39) | < 0.05 | |
| 2HG/tCr | 23, 7 | 0.93 (0.81,1.15) | 0.81 (0.78,0.87) | NS | |
| Vol. CNIT2L > 2 (cm3) | 26, 7 | 18.5 (13.9,37.5) | 7.8 (6.5,10.7) | < 0.01 | |
| Vol. T2L (cm3) | 26, 7 | 46.5 (30.6,74.9) | 19.2 (12.3,33.4) | < 0.01 |
2HG, 2-hydroxyglutarate; GABA, γ-aminobutyric acid; tCr, creatine + phosphocreatine; Glu, glutamate; MI, myo-inositol; tCho, phosphocholine + glycerophosphocholine + choline; Gly, glycine; tNAA, N-acetylaspartate + N-acetylaspartylglutamate; mIG, MI + Gly; CNI, choline-to-NAA index; Vol, volume; NS, not significant