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. 2022 Jun 16;96(9):2523–2543. doi: 10.1007/s00204-022-03321-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 10 — Simplified schematic summary of qRT-PCR and LC–MS/MS results after slice incubation with chlorpromazine (CPZ, purple), cyclosporin A (CSA, yellow), glibenclamide (GB, green) in the presence of the humanized bile acid (BA) mixture. Increased gene expression or increased intracellular concentration BAs (+), decreased gene expression or decreased intracellular concentration BAs (−). Multidrug canalicular efflux transporters bile salt export pump (BSEP), and multidrug resistance-associated protein (MRP), sodium-taurocholate cotransporting polypeptide (NTCP)