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. 2022 Jul 26;12:12761. doi: 10.1038/s41598-022-16840-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Expression of SOD1 antioxidant enzyme is elevated in the chronic active rim of MS lesions. (A) Representative confocal images of NAWM, inactive Core, and active rim of an MS lesion labeled with CD45 for immune cells (green), SOD1 (red) and DAPI (blue). (B) Bar graphs comparing the percent of field of view (FOV) that is CD45⁺, SOD1⁺, and CD45⁺SOD1⁺. Scale bar = 100 µm. Data are shown as mean ± S.D, n = 3 MS patients. Significance indicated as *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, One-way ANOVA with Tukey's post-hoc test.