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. 2022 Jul 26;13:4233. doi: 10.1038/s41467-022-31707-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Summary of cell subpopulation- specific gene regulation. b, c Dotplot representation of single-cell expression profile of genes associated with geographic atrophy or neovascular AMD (b) and of genes associated with biological processes of interest (c) in geographic atrophy (GA) and in control iPSC-derived subpopulations. Dotplots in b and c represent scaled average expression (z-scores) of genes, and percentage of cells in the cluster that express the gene in each subpopulation and condition. Blue end of the color scale represents below-average expression, and the red end of the scale represents above-average expression. Levels of gene expression per cell are shown with color gradients, and frequencies of cells expressing the respective gene (% expressed) are shown with size of dots. In b, significance is shown with colored background.