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. 2022 Jul 26;13:4233. doi: 10.1038/s41467-022-31707-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Schematic representation of respiratory chain complexes showing proteins that were significantly upregulated in geographic atrophy. Illustration adapted from “Electron Transport Chain”, by BioRender.com (2022). Retrieved from https://app.biorender.com/biorender-templates. b Representation of enriched biological processes (Gene Ontology) related to mitochondrial function identified using STRING analysis, yellow circles depict downregulated proteins in geographic atrophy. c–g Entire local network clustering (STRING) with enriched pathways for oxidative phosphorylation (c); hormone metabolic process (d); lipid biosynthesis (e), cholesterol metabolism (f), and gluconeogenesis (g). Significantly upregulated proteins in geographic atrophy are highlighted in blue; downregulated depicted in yellow. STRING networks were generated using Biological Process (GO) or KEGG data obtained from analysis of the most significantly up- and downregulated proteins from the proteomic screen (Supplementary Data 1). h Annotated volcano plot of the 25 most significantly differentially expressed proteins (based on combined P value and fold-change criteria). Upregulated proteins in geographic atrophy are shown in red, and downregulated proteins in blue. Statistical significance established using two-tailed t tests. Source data are provided as a Source Data file.