Fig. 5. Prioritization of geographic atrophy risk genes.

Genes that are significant after Bonferroni correction are highlighted with red dots, with the nearest gene names in black text (previously implicated genes), of which not genome-wide significant in the per-SNP analysis (top GWAS SNP P value < 5 × 10⁻⁸) are highlighted in red text (novel genes identified). The x axis is the genome position from chromosome 1 to chromosome 22, the y axis is the TWAS P value in log-log scale. The maroon horizontal dash line is the Bonferroni correction level. Evidence for association was computed as a Z-score, which was then converted to a two-sided P value. P values were then adjusted for multiple testing using the Bonferroni method (approximately 19,000 genes in each subpopulation).