Table 1.
Underlying mechanism of the disease | ECG | Chest X-ray | CT scan | Echo | CMR | Nuclear (SPECT/PET) |
---|---|---|---|---|---|---|
VHD-Libman-Sacks endocarditis | No | No | Yes, if large | Yes | Yes | PET, yes, if large |
Pericardial effusion | No—just a very large one | Yes | Yes | Yes | CT aspect of PET, if large | |
Pericarditis—inflammation | Severe ones | No | No | No | Yes | PET, if severe |
Noncalcified constrictive physiology of the pericardium | No | No | No | Yes | Yes | No |
RV dysfunction | Late | Late | Late | Yes, but not always | Yes | No |
LV dysfunction | Late | Late | Late | Not subclinical | Yes | Late |
Myocardial edema | No | No | No | No | Yes | No |
Myocardial ischemia | Yes | No | No | Yes, indirectly | Yes | Yes |
Myocardial infarction | No smaller ones | No | No | Yes, not small or subendocardial | Yes | Yes, but not small or subendocardial |
Myocarditis | No | No | No | No, just large ones | Yes | SPECT—No* PET—Yes |
Coronary artery disease | Yes | No | Yes-CCTA | Not directly | Yes | Not directly |
Microvascular dysfunction | Yes | No | No | No | Yes | Only PET |
Aortic involvement | No | Large ones | No, in subclinical cases | Aortic root, no in subclinical cases | Yes | No |
Pulmonary arteries | No | Late | Yes-CTA till distal branching | Main trunk and branches | Yes-till proximal branching | No |
Pulmonary hypertension | Late | Late | Late | Yes | Yes | No |
Radiation free | Yes | No | No | Yes | Yes | No |
Availability | ++++ | ++++ | +++ | ++++ | +++ | ++ |
Costs | + | + | ++ | ++ | ++/+++ | +++/++++ |
Claustrophobia | No | No | Yes—very rare | No | Yes | Yes—rare |
Renal function contraindication | No | No | Yes | No | No** | No |
Implantable (metal) devices contraindication | No | No | No | No | No** | No |
Recommended for routine use in younger people than 65 years old, mainly women—radiation risk | Yes | Yes | No | Yes | Yes | No |
Reproducibility | Yes | Yes | Yes | No-operator dependent | Yes | Yes |
Prognostic information | No | No | No | Yes | Yes | Yes |
SPECT had the technique of Gallium-67, currently obsolete due to inherited limitations of the study; Tc99m could be helpful in some cases.
Currently, there are no absolute contraindications, contrast media could be used in renal impairment, and MRI scanning is possible with implantable devices. See dedicated literature for details and specifications.