TABLE 3.

Liver fibrosis, pulmonary vascular remodeling, low ambient cardiovascular disease, multiple sclerosis, ischemia, and osteoporosis.

Non-coding RNA	Non-coding RNA function	Pathology	Resveratrol effect	Final effect	References
miR-20a	Promote disease progression	Liver fibrosis (LF)	↓ miRNA	Autophagy induction and activation of miR-20a-mediated PTEN/PI3K/AKT signaling pathway to attenuate LF in rat liver	Zhu et al., (2020a)
miR-638	Anti-proliferative effect	Pulmonary hypertension	↑miRNA	Prevention of pulmonary vascular remodeling by regulating NR4A3/cyclin D1 pathway in rat	Liu et al., (2020)
miR-149-5p	Unknown	Ischemia	↑miRNA	Protection against ischemia by up-regulation of Sirt1/miR-149-5p signaling in rat brain	Teertam et al., (2020)
miR-20b	Anti-angiogenic	Ischaemic myocardium	↑miRNA	Anti-angiogenic effects through miR-20b/HIF-1α/VEGF axis in rat	Mukhopadhyay et al., (2012)
miR-328	Hypertophy-associated miRNA	Myocardial Hypertrophy	↓ miRNA	Attenuation of myocardial hypertrophy by inhibiting cardiomyocyte apoptosis in murine models of cold-induced cardiac hypertrophy	Yin et al., (2015)
miR-124	Neuroprotective effect	Multiple sclerosis	↑miRNA	Multiple sclerosis attenuation by altering the miR-124/Sphingosine Kinase 1 Axis in murine models of multiple sclerosis	Gandy et al., (2019)

The function of miRNAs, in the column “miRNA, function” is referred to the specific pathology reported in the table.

PTEN, phosphatase and tensin homolog; P13K, Phosphoinositide 3-kinase; NR4A3, Nuclear Receptor Subfamily 4 Group A Member 3; SIRT1, Sirtuin 1; HIF-1α, Hypoxia Inducible Factor 1 Subunit α; VEGF, Vascular Endothelial Growth Factor; ↑, increased expression/activity; ↓, decreased expression/activity.