TABLE 4.
Cancer
| Non-coding RNA | Non-coding RNA function | Pathology | Resveratrol effect | Final effect | References |
|---|---|---|---|---|---|
| miR-122-5p | Tumor suppressor | Breast cancer (BC) | ↑miRNA | ↓ of key anti-apoptotic (Bcl2) and cell cycle arrest proteins (CDKs) in adriamycin-resistant BC cells | Zhang et al., (2019b) |
| miR-34a, miR-424, miR-503 | Tumor suppressors | Breast cancer (BC) | ↑ all miRNAs | ↓ tumor-associated factor A1 (HNRNPA1) in MCF-7 and MDA-MB-231 breast cancer cells | Otsuka et al., (2018) |
| miR-125b-5p, miR-200c-3p, miR-409-3p, miR-122-5p miR-542-3p | Tumor suppressors | Breast cancer (BC) | ↑ all miRNAs | ↓ anti-apoptotic proteins, Bcl2 and XIAP in MCF-7 and MDA-MB-231 breast cancer cells | Venkatadri et al., (2016) |
| miR-34a | Tumor suppressor | Ovarian cancer (OC) | ↑miRNA | ↓ anti-apoptotic proteins Bcl2 in OC cells | Yao et al., (2021) |
| PCAT29 (lncRNA) | Decreases both proliferation and migration of PC cells | Prostate cancer (PC) | ↑ lncRNA | Inhibition of signaling pathway, IL-6/STAT3/miR-21, that mediate PCAT29 suppression DU145, LNCaP, and RWPE-1 PC cells lines | Al Aameri et al., (2017) |
| miR-17 family | Oncogenic | Prostate cancer (PC) | ↓ miRNAs | Restoration of tumor suppressor gene PTEN in DU145 and 22Rv1 PC cells lines | Dhar et al., (2015) |
| DIO3OS (lncRNA) | Promotes EMT | Benign prostatic hyperplasia (BPH) | ↑ lncRNA | Reversion of EMT in benign prostatic hyperplasia epithelial cells | Chen et al., (2021) |
| miR-96 | Unknown | Colorectal cancer (CRC) | ↑miRNA | Inhibition of KRAS in genetically engineered mice | Saud et al., (2014) |
| CCAT1 CRNDE, HOTAIR PCAT1 PVT1 SNHG16 | LncRNAs associated with colorectal cancer | Colorectal cancer (CRC) | ↓ lncRNAs | Inhibition of cancer cells proliferation by repressing expression of LncRNAs in CRC cell line HT-29 | Cesmeli et al., (2022) |
| miR-200 family | Tumor mediators | Pancreatic cancer (PACA) | ↓ miRNAs | Inhibition of tumor cells migration, invasion and EMT in PACA cell line AsPC-1 | Fu et al., (2019a) |
| NEAT1 (lncRNA) | Tumor inducer | Myeloma | ↓ lncRNA | Reversion of the negative effect of NEAT1 through the Wnt/β-catenin signaling pathway in multiple myeloma (MM) cells | Geng et al., (2018) |
| miR-221 | Oncogenic | Melanoma | ↓ miRNAs | Suppression of melanoma by inhibiting NF-κB/miR-221 in melanoma cell lines A375 and MV3 | Wu and Cui, (2017) |
| AK001796 | Oncogenic | Lung cancer | ↓ lncRNA | inhibition of cancer cell growth in lung cancer cells A549 | Yang et al., (2015) |
| miRNA-520h | Oncogenic | Lung cancer | ↓ miRNA | Inhibition of transcriptional factor FOXC2 in lung cancer cells | Yu et al., (2013) |
The function of miRNAs in the column “miRNA function” is referred to the specific pathology reported in the table.
Bcl-2, B-cell leukemia/lymphoma-2 (apoptosis suppressor); CDKs, cyclin-dependent kinases (cell cycle regulators); HNRNPA1, Heterogeneous nuclear ribonucleoprotein A1; XIAP, X-linked inhibitor of apoptosis protein; PTEN, Phosphatase and tensin homolog; EMT, Epithelial to Mesenchymal Transition; Kras, Kirsten rat sarcoma virus (proto-oncogene); NF-κB, Nuclear factor kappa B; FOXC2, Forkhead box protein C2; ↑, increased expression/activity; ↓, decreased expression/activity.