Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 13;13:909180. doi: 10.3389/fendo.2022.909180

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Doornebal, Harris, Riva, Jagatia, Pizanias, Prachalias, Menon, Preziosi, Zamalloa, Miquel, Zen, Orford, Eaton, Heaton, Ramage, Palma, Srirajaskanthan and Chokshi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The release of soluble checkpoint receptors (solCRs) by LM-NEN PCTS is dependent on the presence of tumour epithelium. (A) Histological assessment of the content of stroma and epithelium in LM-NEN PCTS at day 3 or 5 in culture (see Figure S3 for images related to HCC with prevalent stroma). (B) solCRs quantified in supernatants at day 3 in culture derived from LM-NEN slices with prevalent epithelium (n_patients=3) and slices with prevalent stroma (n_patients=4, 2 LM-NEN + 2 primary liver cancer). Each datapoint indicates the average of 3 technical replicates (slice supernatants) per patient. LM-NEN in blue and grey, stroma primary liver cancer in red. P values following the comparison of stroma slices vs epithelial LM-NEN slices are indicated in graphs.