FIGURE 4.

Lung iPSC-derived organoid composition: (A)—The structure of human LOs and their cellular composition. The scheme shows selected major cell types forming in published iPSC-derived LOs models, including club cells, goblet cells, basal cells, alveolar epithelial cells 1 and 2, multiciliated epithelial cells, lung progenitor cells, and mesenchymal cells. While human lung tissue comprises more than 40 different cell type, including infiltrating immune cells, the iPSC-derived organoids models provide unique opportunity to study the “tissue” without the infiltrating hematopoietic cells. Although, iPSC-derived organoids represent excellent in vitro model, they do not fully mimic the human lung tissue complexity. (B)—Main function of mentioned cell types in human the lung.