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CAR-T therapy in patient with kidney transplants. Immunosuppression agents need to be minimized 2-3 weeks before leukapheresis (1), to ensure the efficacy of CAR-T manufacturing (2). Lymphodepleting chemotherapy (3) will be administered 3-5 days before CAR-T infusion (4). Risk of acute kidney injury (AKI) and rejection is high during peri-infusion period, along with cytokine release syndrome (CRS). Anti-IL-6 treatment can be used for treatment of CRS.
