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. 2022 Jul 13;13:923091. doi: 10.3389/fphys.2022.923091

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Copyright © 2022 Kuzmiszyn, Selli, Smaglyukova, Kondratiev, Fuskevåg, Lyså, Ravna, Tveita, Sager and Dietrichs.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Temperature-dependent inhibition of PDE3 and cAMP-efflux by levosimendan. The does are in logarithm of the concentration in mol/L, presented as means ± SEM. (A) Inhibition curves for PDE3-activity at temperatures ranging from 37°C to 20°C. (B) Inhibition curves for PDE3-activity in % of normothermic inhibition curve at temperatures ranging from 37°C to 20°C. (C) Inhibition curves for ABCC4-activity at temperatures ranging from 37°C to 20°C. (D) Inhibition curves for ABCC4-activity in % of normothermic inhibition curve at temperatures ranging from 37°C to 20°C.