Table 3.
Comparison of clinical characteristics between mNGS and blood culture (positive and negative).
| mNGS and culture-negative (N=38) | mNGS or culture-positive (N=86) | χ2/U | P | |
|---|---|---|---|---|
| Age | 56.00 (51.00,68.00) | 58.00 (51.00,67.00) | 1526.000 | 0.558 |
| Female | 14 (36.84%) | 29 (33.72%) | 0.113 | 0.838 |
| Fever | 12 (31.58%) | 22 (25.58%) | 0.476 | 0.517 |
| Heart rate | 92.00 (84.00,120.00) | 102.50 (90.00,120.00) | 1432.000 | 0.273 |
| Medical history | ||||
| immune-related diseases | 4 (10.53%) | 26 (30.23%) | 5.580 | 0.022 |
| Coronary heart disease | 6 (15.79%) | 11 (12.79%) | 0.200 | 0.778 |
| Hypertension | 10 (26.32%) | 38 (44.19%) | 3.547 | 0.073 |
| Diabetes | 4 (10.53%) | 20 (23.26%) | 2.736 | 0.139 |
| Surgery | 16 (42.11%) | 44 (51.16%) | 0.866 | 0.436 |
| Disease and severity assessment scores | ||||
| Admission APACHE II score | 17.00 (16.00,19.00) | 18.00 (16.00,23.00) | 1309.000 | 0.077 |
| Biochemical indicators | ||||
| WBC | 11.58 (8.87,13.20) | 10.48 (6.31,17.34) | 1589.000 | 0.807 |
| Procalcitonin | 3.40 (0.36,17.00) | 1.20 (0.57,8.06) | 1590.000 | 0.812 |
| C-reactive protein | 113.00 (27.61,249.10) | 74.50 (16.20,149.17) | 1419.000 | 0.244 |
| Platelets | 179.00 (127.00,268.00) | 145.50 (65.00,223.00) | 1287.000 | 0.060 |
| Neutrophil% | 84.30 (71.50,90.60) | 86.75 (73.10,91.90) | 1533.000 | 0.584 |
| Aspartate | 23.00 (16.00,50.00) | 26.50 (17.00,54.00) | 1539.000 | 0.606 |
| Bilirubin | 11.90 (6.50,21.70) | 13.86 (8.50,20.50) | 1443.000 | 0.301 |
| Creatinine | 91.00 (58.00,145.00) | 78.50 (54.00,134.00) | 1440.000 | 0.293 |
| Myoglobin | 272.50 (43.04,707.50) | 228.15 (60.00,553.30) | 1623.500 | 0.955 |
| Cholinesterase | 4.20 (2.90,7.00) | 4.10 (2.70,5.80) | 1530.000 | 0.573 |
| Brain natriuretic peptide | 411.00 (240.00,2202.00) | 1026.00 (278.40,4206.00) | 1316.000 | 0.085 |
| Prothrombin time | 11.70 (10.80,15.30) | 12.85 (11.40,14.80) | 1444.000 | 0.303 |
| Fibrinogen | 3.92 (2.83,5.06) | 3.46 (2.50,4.50) | 1415.500 | 0.236 |
| ICU treatment | ||||
| Use of vasoactive drugs | 30(78.95%) | 75(87.21%) | 1.387 | 0.239 |
| Hemodialysis | 32 (84.21%) | 68 (79.07%) | 0.446 | 0.625 |
| Tracheotomy | 34 (89.47%) | 69 (80.23%) | 1.600 | 0.300 |
| Use of Ventilator | 30(78.95%) | 63(73.26%) | 0.455 | 0.500 |
| 28-day mortality | 14 (36.84%) | 35 (40.70%) | 0.164 | 0.697 |