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. 2022 Jul 13;13:918335. doi: 10.3389/fphar.2022.918335

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Copyright © 2022 Anwaier, Xie, Pan, Li, Yan, Wang, Chen, Weng, Sun, Chang, Fan, Han and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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QSYQ post-treatment inhibited myocardial fiber rupture and cardiac fibrosis. (A) Effects of QSYQ post-treatment on the ultrastructure of myocardial tissues of rats in the Sham4W (a1), Sham10W (a2), Sham10W + TMZ (a3), Sham10W + QSYQ (a4), AAS4W (a5), AAS10W (a6), AAS10W + TMZ (a7), and AAS10W + TMZ (a8) groups. Scale bar = 1 μm. (B) Representative images of Masson’s trichrome staining in the Sham4W (b1 and c1), Sham10W (b2 and c2), Sham10W + TMZ (b3 and c3), Sham10W + QSYQ (b4 and c4), AAS4W (b5 and c5), AAS10W (b6 and c6), AAS10W + TMZ (b7 and c7), and AAS10W + TMZ (b8 and c8) groups. Scale bar = 200 μm. (C,D) Quantification results of interstitial fibrosis and perivascular fibrosis measured by Masson’s trichrome staining. Data are presented as the mean ± SEM, n = 3. ^* p < 0.05 vs. sham; ^# p < 0.05 vs. AAS. AAS, ascending aortic stenosis; C: cardiac myofibril; M: mitochondrial.