TABLE 1.
Targets of QSYQ and its main ingredients on pressure overload-induced cardiac fibrosis.
| Drug | QSYQ | ASIV | R1 | DLA | DO | |
|---|---|---|---|---|---|---|
| Target | ||||||
| Energy | ATP/ADP | * | * | — | — | — |
| ATP/AMP | * | — | — | — | — | |
| Apoptosis | Cleaved caspase-3 | * | — | — | * | * |
| Cleaved caspase-9 | — | — | * | — | ||
| LDH | * | — | * | — | — | |
| MDA | * | * | * | — | ||
| Chemokines | RP S19 | * | — | * | — | |
| MCP-1 | * | — | — | * | — | |
| Fibrosis | TGF-β1 | * | * | — | — | — |
| TGFβR II | * | * | * | * | * | |
| p-Smad3 | * | * | * | * | * | |
| Smad7 | * | — | — | — | — | |
| MMP2 | * | * | * | * | * | |
| MMP9 | * | — | — | — | * | |
| TIMP1 | * | — | — | — | — | |
| TIMP2 | * | — | — | — | — | |
| Collagen I | * | — | * | * | — | |
| Collagen III | * | — | * | * | ||
| FHL2 | * | * | * | * | — | |
*p < 0.05.