. 2022 Jul 27;44(2):268–287. doi: 10.1038/s41401-022-00952-0

Table 1.

Animal models utilized in the study of fibrotic diseases.

Fibrotic diseases

Transgenic animal models

Surgical/drug-induced animal models

Cardiac fibrosis

FAK knockout mice [275];

SR-BI/apoE double KO mice [276];

EC-SOD overexpressing mice [277];

Myocardial ischemia model [278];

Transverse aortic constriction(TAC) model [279];

ISO (Isoproterenol) induced mice [280];

Angiotensin II mice [281];

Skin fibrosis

TSK mutant mice [282, 283];

MRL/lpl/IFNγ receptor null mice [284];

Mutant kinase deficient type II TGF-β receptor transgenic mice [285];

Radiation ulcers [77];

Bleomycin-induced skin fibrosis [286];

Skin wound healing models [287]:

Vinyl chloride induced model [288];

Liver fibrosis

TbRIIDk transgenic mice [289];

HBV transgenic mice [290];

CCl₄ mouse model [291];

Diethylnitrosamine (DEN) rat model [104];

Bile duct ligation (BDL) model [292];

Lung fibrosis

TNF- overexpressing mouse [293];

TGF-β- overexpressing mouse [294];

IL-1-overexpressing mouse [295];

Bleomycin-induced mice model [296];

Silica aerosolized model [297];

FITC induced model [298];

Irradiation-induced pulmonary fibrosis [299];

Human fibroblasts transplantation in immunodeficient mice [300];

Renal fibrosis

Bradykinin B1 receptor deficient mice [301];

TGF-β- overexpressing rat [302];

Nep25 transgenic mice [303];

AT1 receptor-deficient mice [304];

Coll-GFP mice [305];

Drug induced models [306]: (HgCl₂, Vanadate, Adriamycin, Uranyl nitrate, Folic acid etc.);

Surgical induced models: Ureteral obstruction (UUO) rodent model [307]; kidney ischemia mice [308];

Myelofibrosis (bone marrow)

TPO(Thrombopoietin)-overexpressing mice [309];

GATA-1^low mice [310];

Calr^del52 mice [311];

Abi-1 knockout mouse [312];

JAK2^V617F murine bone marrow transplantation model [313];

MPL^W515L murine bone marrow transplantation model [314];

Cystic fibrosis (airway)

PTEN-long–deficient mice (Ptenl^−/−) [115, 125];

Cftr^ΔF508 mutation mice [315];

Ovalbumin-exposed mice [316];

Intestinal fibrosis

IL-10 KO mice [317];

TGF-β1- overexpression mice [318];

Organoid-based epithelial to mesenchymal transition (OEMT) model [319];

Trinitrobenzene sulfonic acid (TNBS) model [320];

Salmonella typhimurium models [321];

Radiation-Induced rat model [322];

Pancreatic fibrosis

R122H transgenic mice [323];

DBTC induced model [324];

Caerulein-induced model [325];

Oleic acid-induced model [326];

Cerulein-induced model [327];