Table 2.
Clinical trails of MSC treatment in fibrotic diseases
| Disease type | Clinical trial info | MSC info | Reference | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Lesion | Indication | Phase | Country | Status | Year | Tissue Origin | Dose range | Clinical Trail database | Ref |
| Liver | Cirrhotic Patients With Pioglitazone | IIT Phase I | Iran | Completed | 2011-2014 | Autologous Bone marrow | Not specified | NCT01454336 | |
| Liver Cirrhosis | IIT Phase I | China | Completed | 2011-2014 | Allogeneic Menstrual Blood | 1 × 106 cells/kg per dose, 4 doses | NCT01483248 | ||
| Decompensated Liver Cirrhosis | IIT Phase II | India | Ongoing | 2019- | Allogeneic Umbilical Cord | Not specified | NCT03945487 | ||
| Decompensated Liver Cirrhosis | Phase I/II | Japan | Ongoing | 2017- | Allogeneic Adipose | Not specified | NCT03254758 | ||
| Liver cirrhosis | Phase I/II | Singapore | Ongoing | 2018- | Autologous Bone marrow | (0.5–1) × 106 cells/kg | NCT03626090 | ||
| Decompensated liver cirrhosis | IIT Phase I | Iran | Completed | 2007 | Autologous Bone marrow | 0.5 × 106 cells/kg | Not registered | [257] | |
| Liver cirrhosis | IIT Phase I | China | Completed | 2010-2018 | Allogeneic Umbilical cord | 0.5 × 106 cells/kg | NCT01220492 | ||
| Decompensated liver Cirrhosis | IIT Phase I | India | Completed | 2020-2020 | Autologous Bone marrow | Not specified | NCT04243681 | ||
| Alcoholic Cirrhosis | Phase III | Korea | Ongoing | 2020- | Autologous Bone marrow | 7 × 107 cells/dose | NCT04689152 | ||
| Liver Cirrhosis Patient Caused by Hepatitis B | IIT Phase I | Indonesia | Ongoing | 2020- | Allogeneic Umbilical Cord | 1 × 108 cells/dose | NCT03472742 | ||
| Liver Cirrhosis | Phase I | Iran | Completed | 2007-2009 | Autologous Bone marrow | Not specified | NCT00420134 | ||
| Hepatitis B liver cirrhosis | IIT Phase I | China | Ongoing | 2019- | Allogeneic Umbilical Cord | 6 × 107 cells/dose | NCT03826433 | ||
| Liver Cirrhosis | Pilot | Japan | Completed | 2010-2015 | Autologous Adipose | Not specified | NCT01062750 | ||
| Alcoholic liver cirrhosis | IIT Phase I | USA | Ongoing | 2019- | Autologous Bone marrow | 5 × 107 cells/dose | NCT03838250 | ||
| Decompensated liver cirrhosis | IIT Phase I | China | Ongoing | 2022- | Allogeneic Umbilical Cord | (5–15) ×107 cells/dose | NCT05227846 | ||
| Liver cirrhosis | IIT Phase I | Vietnam | Ongoing | 2022- | Allogeneic Umbilical Cord | Not specified | NCT05331872 | ||
| Liver cirrhosis | IIT Phase I | China | Ongoing | 2021- | Allogeneic Umbilical Cord | 1 × 108 cells/dose, 2 doses | NCT04541680 | ||
| Decompensated alcoholic cirrhosis | Ongoing | 2021- | Allogeneic Umbilical Cord | (0.5–2) ×106 cells/kg | NCT05155657 | ||||
| Liver cirrhosis | IIT Phase I | Sweden | Completed | 2006-2009 | Autologous Bone marrow | 5 × 107 cells/dose | Not registered | [256] | |
| Lung | Idiopathic Pulmonary Fibrosis | IIT Phase I | Spain | Completed | 2013-2018 | Autologous Bone marrow | (1–10) × 107 cells/kg | NCT01919827 | [259] |
| Radiation-induced Pulmonary Fibrosis | IIT Phase I | China | Completed | 2014-2019 | Allogeneic Umbilical cord | 1 × 106 cells/kg | NCT02277145 | ||
| Idiopathic Pulmonary Fibrosis | IIT Phase I | Australia | Completed | 2011-2015 | Allogeneic Placenta | (1–2) × 106 cells/kg | NCT01385644 | ||
| Idiopathic Pulmonary Fibrosis | IIT Phase I | USA | Completed | 2013-2017 | Allogeneic Bone marrow | (2–20) × 107 cells/kg | NCT02013700 | [258] | |
| Idiopathic Pulmonary Fibrosis | IIT Phase I | USA | Recruiting | 2021- | Allogeneic Umbilical Cord | 1 × 106 cells/kg | NCT05016817 | ||
| Bleomycin Induced Pulmonary Fibrosis | Phase I/II | India | Ongoing | 2014- | Autologous Adipose | 2 × 106 cells/kg per dose, 3 doses | NCT02625246 | ||
| Interstitial lung disease | IIT Phase I | Russia | Completed | 2015-2018 | Allogeneic Bone marrow | 2 × 108 cells/kg | NCT02594839 | ||
| Systemic | Diffuse Cutaneous Systemic Sclerosis | IIT Phase I | Colombia | Ongoing | 2020- | Allogeneic Wharton ´s jelly | 2 × 106 cells/kg | NCT04432545 | |
| Cystic Fibrosis | IIT Phase I | USA | Completed | 2016-2020 | Allogeneic Bone marrow | (1–5) × 106 cells/kg | NCT02866721 | ||
IIT Investigator initiated trials