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Strategies for resistance to BRAF inhibitors.
| Situation | Strategies | Ref. |
|---|---|---|
| BRAF fusion | pan-RAF inhibitors | (75) |
| BRAF inhibitors and RAF inhibitors | (76, 77) | |
| combination of MEK inhibitors and EGFR inhibitors | (25, 77) | |
| Acquired drug resistance to vemurafenib | intermittent dosing | (78–80) |
| Changes in multiple key tumorigenesis pathways and mechanisms | low toxicity “broad-spectrum” treatment | (81) |
| Resistant mutations at different gene target | different drug combinations | (82) |
