Table 2.

Placental malaria decreases non-classical monocyte sub-populations.

	Odds Ratio	p value	95% Confidence Interval
Classical monocytes
Pf infection at sample collect	0,781	<0.001	[0.711; 0.858]
Pf infection in placenta	1,146	0,013	[1.029; 1.275]
Intermediate monocytes
Pf infection at sample collect	1,383	0,007	[1.090; 1.755]
Pf infection in placenta	0,838	0,113	[0.675; 1.042]
Non classical monocytes
Pf infection at sample collect	1,559	<0.001	[0.581; 1.999]
Pf infection in placenta	0,735	0,010	[0.581; 0.930]

Adjusted mixed models were used to assess the role of placental malaria on the frequency of monocyte sub-populations at 18 and 24 months of age for 146 infants. Mixed models are used to take into account repetitive measurements for a same individual (dependent variable). For each monocyte sub-population, one model was performed taking into account active Pf infection at the sample collection. Respectively 16 and 25 Pf infections were reported at 18 and 24 months among which 10 and 6 were symptomatic Pf infections. The model was adjusted on age, gender, birth weight, maternity, ethnicity, maternal anemia, maternal IPTp and environmental exposure. The lincom command (Stata^® Software, Version 13 (StatCorp LP, College Station, TX, USA)) was used to compute coefficient values in odds ratios (OR). OR > 1 means that the frequency of monocyte sub-population increases while the frequency of monocyte sub-population decreases if OR<1. Significant differences are marked in bold (p<0.05).