Table 2.

Listing of proteins found in ECM, percent composition, and the general functions within the ECM of the integument. Note that varying degrees of composition can occur because of the location of ECM.

Protein	Percent Composition	Function(s)
Collagen(s)	50–90	Synthesized by fibroblasts. Gives structural and tissue integrity, aids in epidermal/dermal differentiation.
Elastin	0.6–7.9	Creates an intricate network for structural support allowing for elasticity of tissue.
Fibronectin	<1.0	Involved in wound healing including platelet spreading and leukocyte migration to injured tissue(s). Aids in promotion of elastin deposition and mechanical strength of ECM.
Laminin	<1.0	A glycoprotein that is a part of the basal lamina, aids in cellular signaling.
Vitronectin	<1.0	A glycoprotein involved in hemostasis and cellular adhesion during tissue damage.
Tenascin	<1.0	Glycoprotein family that aids in cellular migration adhesions and cell proliferation.