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. Author manuscript; available in PMC: 2022 Jul 27.
Published in final edited form as: Cell Rep. 2022 Jun 7;39(10):110930. doi: 10.1016/j.celrep.2022.110930

Figure 1. DENV4 GI and II phylogeny and virus design.

Figure 1.

A) Maximum likelihood phylogeny of envelope protein sequences of DENV4 viruses detected during CYD14 (blue dots) and CYD15 trial (green dots). The tree also depicts the positions of the DENV4 vaccine virus envelope (CYD4, purple), and the DENV4 infectious clone (Lab IC), DENV4 GI (Lab GI) and DENV4 GII (Lab GII) envelopes on recombinant viruses used in the current study. The tree was created using Geneious version 2019.0 B) Design of recombinant GI and II viruses.