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. Author manuscript; available in PMC: 2022 Jul 27.
Published in final edited form as: Cell Rep. 2022 Jun 7;39(10):110930. doi: 10.1016/j.celrep.2022.110930

Figure 5. Pre-vaccination serostatus alters tracking with signature amino acids.

Figure 5.

A) Seronegative and seropositive vaccination sera neutralization of wild-type and chimeric GI and II viruses. FRNT50 represents sera dilution factor required to neutralize 50% of virus. Dotted line represents limit of detection (20). Samples not neutralized are graphed at ½ the limit of detection (10). One-way ANOVA with Tukey’s multiple comparison test (****p<0.0001). B) Seronegative and seropositive vaccination sera chimeric virus relative titer = (chimeric FRNT50 / parental wild-type FRNT50). Relative titer < 1 = parental wild-type virus better neutralized, relative titer > 1 = chimeric better neutralized. Relative titers were compared with an unpaired t-test (**p<0.005).