Table 1.
The recommended minimum (Min) and maximum (Max) quantities of each selected disintegrant for tablet formulations and the mass of each disintegrant per 50 ml volume of each test solution prepared for the transport studies.
| Disintegrant | Recommended concentration (% w/w) in tablet | Mass (mg) | ||
|---|---|---|---|---|
|
| ||||
| Scenario 1 | Scenario 2 | |||
| Ac-di-sol® (ADS) (Croscarmellose sodium) | Min | 0.50 | 0.50 | 0.25 |
| Max | 5.00 | 5.00 | 2.50 | |
| Avicel® PH-200 (AVC) (Microcrystalline cellulose) | Min | 5.00 | 5.00 | 2.50 |
| Max | 15.00 | 15.00 | 7.50 | |
| Explotab® (XPT) (Sodium starch glycolate) | Min | 2.00 | 2.00 | 1.00 |
| Max | 8.00 | 8.00 | 4.00 | |
| Kollidon® CL-M (KLM) (Crospovidone) | Min | 2.00 | 2.00 | 1.00 |
| Max | 5.00 | 5.00 | 2.50 | |
| Sodium alginate (SAL) | Min | 2.50 | 2.50 | 1.25 |
| Max | 10.00 | 10.00 | 5.00 | |