Table 2.

Recent studies on effectiveness of resveratrol in the treatment of asthma

Study	Model	Approach	Results
Lee et al., 2009	Animal: mice of BALB/c strain	The therapy comprised of 4 mg/kg of dexamethasone and 30 mg/kg of resveratrol; asthma induced by egg protein	Reduction of IgE, IL-4 and IL-5 concentrations; lower Penh values, reduction in cell infiltration; eosinophilia alleviation; the efficiency slightly lesser in comparison with dexamethasone pharmacotherapy
Chen et al., 2015	Animal: rodents	Administration of dexamethasone at a dose of 1 mg/kg and resveratrol at a dose of 50 mg/kg; asthma induced by house dust mites	Reduction in: inflammation, fibrosis progression and concentration of TNF-α, TNF-β, IL-6 and IL-16; the effectiveness of polyphenol and dexamethasone was comparable
Lee et al., 2017	Animal: mice	Administration of resveratrol at a dose of 10 mg/kg or 50 mg/kg/day; asthma induced by egg protein	Reduction in inflammation, inhibition of respiratory tract remodelling progression, reduction in collagen, IL-4, IL-5, IL-13 and TGF-β1 concentrations, reduction in eosinophilia
Ni et al., 2016	Animal: mice of BALB/c strain	Administration of resveratrol at a dose of 30 mg/day for 6 days; asthma induced by egg protein	Reduction of inflammation, inhibition of mucogenesis by reducing mucin concentration
Royce et al., 2011	Animal: mice of BALB/c strain	A 6-week pharmacotherapy of resveratrol at a dose of 12.5 mg/day; asthma induced by egg protein	Slightly increased concentration of inflammatory cells, eosinophils and IgE, reduction in neutrophils and monocytes concentration, reduction in AHR and respiratory tract fibrosis progression
Andre et al., 2016	Animal: mice of C57/Bl16 strain; co-occurring obesity in some individuals	Administration of resveratrol at a dose of 100 mg/kg for 14 days; asthma induced by egg protein; normal or high-fat diet	Reduction in inflammation and eosinophils concentration; polyphenol exhibited more efficient activity in mice on a high-fat diet, inhibition of nitric oxide synthase activity and TNF-α only in mice on a high-fat diet
Li et al., 2018	Animal: rats with co-occurring obesity	Food containing polyphenol at a concentration of 0.03%	Reduction in ROS concentration, antioxidant defence enhancement
Joskova et al., 2013	Animal: guinea pigs	Comparison of resveratrol’s and quercetin’s effectiveness; administration of resveratrol at a dose of 10 mg/kg/day, quercetin at a dose of 20 mg/kg/day and preparations containing polyphenols at doses of 2 ml/kg and 20 mg/kg; asthma induced by egg protein	Reduction in muscle tone, smaller respiratory tract reactivity, reduction in IL-4 and IL-5 concentration caused by each type of pharmacotherapy; the authors stated that the activity of preparations containing quercetin was stronger than pharmacotherapy based solely on polyphenols