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PAD and biomarker levels at 5-year MRI in patient subgroups. (A and B) PAD in WBGM and WBWM and (C and D) levels of GFAP and NFL at >5-year MRI in subgroups of patients who showed improving (Improve; increase in GOSE ≥ 1 point), stable (no change in GOSE), or worsening (Worse; reduction in GOSE ≥ 1 point) between ∼8 months and >5 years post-injury. HV = healthy volunteers. Figures above box plots show unadjusted P-values for comparisons (Mann-Whitney U).
