Figure 1.

Anti-VLA-4 antibodies can potentially abrogate transendothelial and intra-tissular T cell migration and adhesion. 1. Extravasation of lymphocytes can be impaired by blocking VLA-4/VCAM-1 interaction at the endothelial of blood vessels; 2. Intratissular migration of lymphocytes in the inflammatory sites can be significantly diminished by blocking VLA-4/fibronectin interaction; 3. Adhesion of the activated lymphocyte to a potential organ specific cell type can be abolished by blocking fibronectin/VCAM-1/VLA-4 mediated cell–cell interaction. EC: endothelial cells; fibronectin is represented by the double waves in the extracellular space.