Figure 1.

Specific CAR molecules for NK cells. (A) CAR with NK-specific signaling molecules. A second-generation CAR is represented, constructs specific for NK cells may contain 2B4, DNAM-1, DAP10, and/or DAP12 as co-stimulatory signaling domains with CD3ζ. The TM domain can also contain specific NK molecules such as CD16, NKp44, NKp46, or NKG2D. (B) NKG2D ectodomain as the recognition domain. A chimeric receptor containing NKG2D with DAP10/DAP12 and CD3ζ is represented. Constructions may contain the entire NKG2D protein as shown or only its ectodomain with a CD8 hinge and transmembrane region.