Table 2.
Clinical trials using CAR-NK cells for gene therapy
| Reference | NK source | Gene transfer | Target molecule | Target tumor | CAR construct | Status | Sponsor | Study Phase |
|---|---|---|---|---|---|---|---|---|
| NCT04796675 | CB | RV | CD19 | CD19+ B-cell malignancies | Unknown | Recruiting | Wuhan Union Hospital, China | I |
| NCT03056339 [125] | CB | RV | CD19 | B Lymphoid Malignancies | CD19-CD28-zeta-2A-iCasp9-IL15 | Recruiting | M.D. Anderson Cancer Center | I/II |
| NCT03656705 | NK92 | RV/LV | Unknown | Non-small Cell Lung Cancer | Unknown | Enrolling by invitation | Xinxiang medical university | I |
| NCT02944162 [156] | NK92 | LV | CD33 | AML | ScFv-CD28-CD137-CD3z | Unknown | PersonGen BioTherapeutics (Suzhou) Co., Ltd. | I/II |
| NCT02839954 | NK92 | LV | MUCI | Solid tumor | ScFv-CD28-CD137-CD3z | Unknown | PersonGen BioTherapeutics (Suzhou) Co., Ltd. | I/II |
| NCT02892695 | NK92 | LV | CD19 | Lymphoma, leukemia | ScFv-CD28-CD137-CD3z | Unknown | PersonGen BioTherapeutics (Suzhou) Co., Ltd. | I/II |
| NCT03383978 [157] | NK92 | LV | HER2 | GBM | ScFv-CD28-CD3z | Recruiting | Johann Wolfgang Goethe University Hospital | I |
| NCT03940833 | NK92 | LV | BCMA | Multiple myeloma | Unknown | Recruiting | Asclepius Technology Company Group (Suzhou) Co., Ltd. | I/II |
| NCT03941457 | NK92 | LV | ROBO1 | Pancreatic Cancer | Unknown | Recruiting | Asclepius Technology Company Group (Suzhou) Co., Ltd. | I/II |
| NCT03940820 | NK92 | LV | ROBO1 | Solid Tumor | Unknown | Recruiting | Asclepius Technology Company Group (Suzhou) Co., Ltd. | I/II |
| NCT04245722 [147] | iPSC | LV | CD19 | B-cell lymphoma, CLL | scFv-NKG2D-2B4-CD3z-IL-15/RhnCD16 | Recruiting | Fate Therapeutics | I |
| NCT00995137 | PB-NK | mRNA electroporation | CD19 | B-ALL | ScFv-CD8aTM-CD137-CD3z | completed | St. Jude Children’s Research Hospital | I |
| NCT02742727 | NK92 | Electroporation | CD7 | Lymphoma, leukaemia | ScFv-CD28-CD137-CD3z | Unknown | PersonGen BioTherapeutics (Suzhou) Co., Ltd. | I/II |
| NCT03415100 [115] | PB-NK | mRNA electroporation | NKG2DL | Metastatic solid tumor | ScFv-CD8aTM-CD3z; ScFvCD8aTM-DAP12 | Unknown | The Third Affiliated Hospital of Guangzhou Medical University | I |