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. 2022 Jan 27;2(1):ltac002. doi: 10.1093/immadv/ltac002

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© The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Immunology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Effect of C19-A3 GNP on β-cell function and metabolic parameters. (a) Serum C-peptide expressed as area under the curve (AUC) over 120 min after mixed-meal challenge; (b) urine C-peptide to creatinine ratio (UCPCR) 2 h after mixed meal; (c) HbA1c; (d) median total daily insulin dose recorded over 3 days before the study visit and normalised for body weight; (e) insulin dose-adjusted A1c (IDAA1c) calculated according to the formula: HbA1c (%) + [4× insulin dose (units per kg per 24 h)]. Each line represents an individual participant with an assigned study number as shown in the legend.