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. Author manuscript; available in PMC: 2022 Jul 27.
Published in final edited form as: Cell Rep. 2022 Jun 28;39(13):111001. doi: 10.1016/j.celrep.2022.111001

Figure 5. Stmn2 KO in motor neurons causes motor pathology.

Figure 5.

(A) Schematic of floxed Stmn2 allele.

(B) Latency time to fall from an inverted screen (max. 120 s) for ChAT-Cre−/Stmn2f/f (n = 9) and ChAT-Cre+/Stmn2f/f (n = 13) mice at 3 months of age. Statistical significance was determined by the Student unpaired t-test.

(C) Representative images of NMJs from 3-month-old ChAT-Cre−/Stmn2f/f (n = 3) and ChAT-Cre+/Stmn2f/f (n = 6) lumbrical muscles. NMJs were visualized by neurofilament/SV2 (green) and bungarotoxin (magenta) staining. Scale bar, 25 μm. Quantification is to the right. All data are presented as mean ± SEM. *p < 0.05, **p < 0.01. See also Figure S4.