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. 2022 Jul 26;13:352. doi: 10.1186/s13287-022-03056-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — miR-126-3p promoted proliferation and inhibited apoptosis of OGCs in vitro and PIK3R2 is a target of miR-126-3p. A. Flow cytometric apoptosis assay was used to analyze the effect of miR-126-3p-hucMSCs-exosomes on OGCs apoptosis. B. Analysis of the ratio of the percentages of apoptotic OGCs in each group. C. EDU assay was used to analyze the effect of miR-126-3p-hucMSCs-exosomes on OGCs proliferation. D. Analysis of ratio of the percentages of proliferative OGCs in each group. E. Comparison of the ratio of apoptosis rate of OGCs as flow cytometric apoptosis assay in each group. F. Comparison of the ratio of proliferation rate of OGCs as EDU assay in each group. G. The mRNA levels of PIK3R2 and SPRED-1 after transfection of miR-126-3p mimics and inhibitor in OGCs. H. Representative western blots of PIK3R2 and SPRED-1 protein expression in OGCs transfected with miR-126-3p mimics and inhibitor. I. The protein levels of PIK3R2 and SPRED-1after transfection of miR-126-3p mimics and inhibitor in OGCs. J. After transfection of miR-126-3p mimic and wild-type or mutant vectors into OGCs, dual-luciferase reporter genes were performed to determine luciferase activity**P < 0.01 versus WT group. *P < 0.05 for all figures