Table 3.

Selected SPIRIT item components with highest absolute improvement in adequate reporting (2016 vs 2012)

SPIRIT component	Belonging to SPIRIT Item Number	2012			2016			Absolute increase
		Industry sponsorship (n=49)	Non-industry sponsorship (n=54)	Total 2012 (n=103)	Industry sponsorship (n=62)	Non-industry sponsorship (n=46)	Total 2016 (n=108)
Basic study design in title	1	31 (63.3%)	9 (16.7%)	40 (38.8%)	53 (85.5%)	24 (52.2%)	77 (71.3%)	32.5%
Name and contact details of sponsor	5b	12 (24.5%)	16 (29.6%)	28 (27.2%)	31 (50.0%)	31 (67.4%)	62 (57.4%)	30.2%
Steering Committee General Membership and Role	5d	35 (71.4%)	45 (83.3%)	81 (77.7%)	56 (90.3%)	39 (84.8%)	73 (98.0%)	20.3%
Of which not applicable		30 (61.2%)	29 (53.7%)	59 (57.3%)	46 (74.2%)	24 (52.2%)	70 (64.8%)
Research question described and justified	6a	11 (22.5%)	9 (16.7%) 2NA	20 (19.4%)	35 (56.5%)	13 (28.3%)	48 (44.4%)	25.0%
Strategies to improve or monitoring of adherence	11c	33 (67.4%)	34 (63.0%)	67 (65.1%)	57 (91.9%)	40 (87.0%)	97 (89.8%)	24.7%
Of which not applicable		9 (18.4%)	25 (46.3%)	34 (33.0%)	23 (37.1%)	28 (60.9%)	51 (41.2%)
Expected recruitment rate	15	7 (14.3%)	15 (14.3%)	22 (21.4%)	20 (32.3%)	25 (45.4%)	45 (41.7%)	20.3%
Method for generation of random sequence	16a	21 (42.8%)	29 (53.7%)	50 (48.5%)	51 (82.3%)	30 (65.2%)	81 (75.0%)	26.5%
Strategies to promote participant retention and complete follow-up	18b	9 (18.4%)	20 (38.0%)	29 (28.4%)	38 (61.3%)	16 (34.8%)	54 (50.0%)	21.6%
Of which not applicable		2 (4.1%)	2 (3.7%)	4 (3.9%)	-	-	-
Data entry and coding	19	11 (22.5%)	9 (15.5%)	20 (18.7%)	49 (79.0%)	20 (43.5%)	69 (63.9%)	45.2%
Process for making amendments described	25	27 (55.1%)	8 (14.8%)	35 (34.0%)	50 (80.7%)	21 (45.7%)	71 (65.7%)	31.7%
Declaration of Interests	28	8 (16.3%)	4 (7.4%)	12 (11.7%)	60 (96.8%)	10 (21.7%)	70 (64.8%)	53.1%
Ancillary and post-trial care	30	4 (8.2%)	8 (14.8%)	12 (11.7%)	29 (46.8%)	31 (67.4%)	60 (55.6%)	43.9%