Table 2.
Integral gene drive system parameters
| Parameter | Description | Default value | Range |
|---|---|---|---|
| d1 | Drive efficiency and transmission rate (applies to both driver and effector target loci) | 1 | 0.9–1 |
| p_nhej | Probability of NHEJ if drive transmission fails | 0.5 | – |
| p_ihdr | Probability of incomplete HDR during homing | 1E−4 | – |
| p_r_nhej | Probability of resistance arising from NHEJ | 1/3 | – |
| p_r_ihdr | Probability of resistance arising from incomplete HDR | 1/3 | – |
| 1—p_r_nhej | Probability of loss of gene function from NHEJ | 2/3 | – |
| 1—p_r_ihdr | Probability of loss gene function from incomplete HDR | 2/3 | – |
| sd1 | Fitness cost of hijacking driver target locus | 0 | – |
| sd2 | Fitness cost of hijacking effector target locus | 0 | – |
| sn | Fitness cost of driver expression | 0.05 | – |
| se2 | Fitness cost of effector expression | 0 | 0–0.5 |
| sm | Fitness cost of loss of gene function | 1 | – |
| hd1 | Dominance coefficient for hijacking at driver target locus | 0.5 | – |
| hd2 | Dominance coefficient for hijacking at effector target locus | 0.5 | – |
| hn | Dominance coefficient for driver expression | 0.5 | – |
| he2 | Dominance coefficient for effector expression | 0.5 | – |
| hm | Dominance coefficient for loss of gene function | 0.2 | – |
| hrc1 | Dominance coefficient for parasite refractoriness | 1 | – |
| rc | Homozygous degree of parasite refractoriness | 1 | 0.5–1 |
| rr10 | Initial population driver target site resistance frequency | 0 | – |
| rr20 | Initial population effector target site resistance frequency | 0 | 0–0.1 |