Fig. 8.

ADSC-derived exosomes blocked TXNIP-mediated cell pyroptosis of macrophages in inflammation induced by Ang II. A Positive GSDMD cells in Ang II-induced AAA mice detected using immunohistochemistry. Scale bar: 50 μm. B, C The level of cleaved GSDMD-N after Ang II treatment detected using western blot analysis D-F The level of TXNIP knockdown was validated by western blot (D-E) and RT-qPCR analysis (F). G–H GSDMD expression in Raw264.7 cells receiving different treatments was evaluated using western blot analysis. I–J Western blot analysis showed the treatment efficacy of exosomal miR-17-5p mimics versus exosomal miR-17-5p inhibitor on GSDMD expression in Raw264.7 cells. K Proposed model for exosomal miR-17-5p from ADSC as a therapeutical strategy of AAA. Repetition = 3; The one-way ANOVA and two-tailed Student’s t-test were performed to compare data between groups. *P value < 0.05, **P value < 0.01, ***P value < 0.001