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. 2022 Jul 27;13:362. doi: 10.1186/s13287-022-03078-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Effect of MSC-TGF-β1 on inflammatory cytokines in the plasma and macrophages in tissue. a, b, c: The levels of IL-6, IL-1β, and IL-10 in the plasma were tested by ELISA (n = 3, *p < 0.05 vs. the sham group; #p < 0.05 vs. the CLP group; &p < 0.05 vs. the MSC-NC group). d, e, f: The levels of macrophages in lung, liver and spleen tissue were assayed by immumohistochemical staining. (n = 3, *p < 0.05 vs. the sham group; #p < 0.05 vs. the CLP group; &p < 0.05 vs. the MSC-NC group). Scale bar = 100 μm. Abbreviations: CLP: cecal ligation and puncture; MSCs, mesenchymal stem cells; MSC-NC: mesenchymal stem cell carrying GFP; MSC-TGF-β1: TGF-β1 overexpressing MSC