Fig. 4.

miR-212-3p directly targets TP53 and MSH2 in EC. A Target prediction for miR-212-3p using bioinformatic software Starbase. B Luciferase activity in cells co-transfected with miR-212-3p mimic and WT or MUT TP53, PUM2, MSH2, LDLR, LATS2, and FOXN3. C, D The expression of MSH2 in cells treated with miR-212-3p mimic or miR-212-3p inhibitor was determined by qPCR (C) or western blotting (D). E The expression of p53 MHS2 in normal and EC tissue was measured by qPCR. F The correlation between miR-212-3p and MSH2 expression in EC tissue. *p < 0.05, **p < 0.01, ***p < 0.001