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. 2022 Jul 27;20:108. doi: 10.1186/s12958-022-00980-9

Fig. 5.

Fig. 5

Characteristics of abnormally differentiated dNK cells in URSA. A Cluster 4 reflected the degree of disordered differentiation of dNK cells. B ECM was an indispensable factor for dNK cell maturation. C Decreased expression levels of KIR2DL1 and KIR2DL3 in Cluster 4 directly affected the state of mature dNK cells. D The mature dNK cells in URSA still had high cytotoxicity and immunoreactivity. E Diagram of the inadequate interaction of dNK cells with EVTs due to ECM deficiency