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Synthesis of 5-carboxybenzo[b]thiophene (compound 3) from p-bromothiophenol. Compound 1, 1-bromo-4-(2,2-dimethoxyethylsulfanyl)-benzene; compound 2, 5-bromobenzo[b]thiophene. NaOMe, sodium methoxide; MeOH, methanol; PPA, polyphosphoric acid; PhCl, monochlorobenzene; Mel, methyl iodide.
