Table 1.
Characteristics and PB counts of community-dwelling individuals at least 60 years old with and without monocytosis as well as 1:3 matched control subjects
| Absence of monocytosis (n = 21 562) | Monocytosis (n = 167) | P value* | 1:3 matched control subjects n = 501 | P value† | N‡ | |
|---|---|---|---|---|---|---|
| Age (y) | 65.0 (62.0-69.0) | 68.0 (63.0-72.0) | <.001 | 68.0 (63.0-72.0) | 1.00 | 21 729 |
| Male sex, n (%) | 9 756 (45.2) | 123 (73.7) | <.001 | 369 (73.7) | 1.00 | 21 729 |
| Monocyte count (109/L) | 0.50 (0.15) | 1.12 (0.12) | <.001 | 0.53 (0.15) | <.001 | 21 729 |
| WBC count (109/L) | 5.83 (1.46) | 8.60 (1.72) | <.001 | 6.08 (1.56) | <.001 | 21 727 |
| Neutrophil count (109/L) | 3.14 (1.08) | 4.88 (1.51) | <.001 | 3.37 (1.22) | <.001 | 21 729 |
| Basophil count (109/L) | 0.03 (0.02) | 0.04 (0.03) | <.001 | 0.03 (0.02) | <.001 | 21 729 |
| Eosinophil count (109/L) | 0.19 (0.13) | 0.25 (0.15) | <.001 | 0.21 (0.14) | .001 | 21 729 |
| Lymphocyte count (109/L) | 1.96 (0.59) | 2.30 (0.77) | <.001 | 1.94 (0.59) | <.001 | 21 729 |
| Hemoglobin concentration (g/dL) | 14.2 (1.15) | 14.6 (1.34) | <.001 | 14.5 (1.25) | .348 | 21 727 |
| Erythrocyte count (109/L) | 4.70 (0.37) | 4.77 (0.43) | .038 | 4.79 (0.39) | .736 | 21 727 |
| Hematocrit (L/L) | 0.43 (0.03) | 0.44 (0.04) | <.001 | 0.43 (0.03) | .153 | 21 727 |
| Platelet count (109/L) | 240 (56.3) | 254 (64.9) | .004 | 229 (51.7) | <.001 | 21 707 |
| MCV (fL) | 90.9 (3.96) | 92.0 (4.16) | .001 | 90.8 (4.21) | .002 | 21 727 |
| hsCRP (mg/L) | 1.40 (0.80-2.90) | 3.20 (1.65-7.75) | <.001 | 1.40 (0.80-2.70) | <.001 | 7 316 |
| Number of medications used§ | 2.00 (0.00-4.00) | 3.00 (1.00-5.00) | <.001 | 2.00 (0.00-4.00) | <.001 | 21 729 |
| Concurrent cytopeniaǁ, n (%) | 2 434 (11.3) | 15 (8.98) | .412 | 66 (13.2) | .194 | 21 708 |
| Concurrent cytosis¶, n (%) | 480 (2.2) | 38 (22.8) | <.001 | 13 (2.6) | <.001 | 21 707 |
hsCRP, high-sensitivity C-reactive protein; MCV, mean corpuscular volume.
Data are presented as mean (SD) or median (IQR) for continuous variables and number (%) for categorical variables.
P value for the comparison of individuals with and without monocytosis.
P value for the comparison between individuals with monocytosis and 1:3 matched control subjects.
Total number of evaluable individuals ≥60 years.
As a proxy for comorbidity.
A concurrent cytopenia was defined as follows: anemia, Hb concentration <12.0 g/dL in women or <13.0 g/dL in men; thrombocytopenia, platelet count <150 × 109/L; neutropenia, absolute neutrophil count <1.8 × 109/L.
A concurrent cytosis was defined as follows: erythrocytosis, Hb concentration >16.5 g/dL or hematocrit ≥48% in women or Hb concentration >18.5 g/dL or hematocrit ≥52% in men; thrombocytosis, platelet count >400 × 109/L; leukocytosis, WBC count >10 × 109/L.