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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: Histopathology. 2022 Jul 11;81(2):246–254. doi: 10.1111/his.14707

Figure 3:

Figure 3:

Figure 3:

Prostate cancer with diffuse neuroendocrine differentiation

Example 1: (A) H&E at 10x magnification highlighting nested/compartmentalized arrangement of cells with abundant amphophilic cytoplasm; (B) diffuse reactivity with NKX3.1, and (C) diffuse reactivity with synaptophysin

Example 2: (D) H&E at 10x magnification showing sheet-like growth of cells with abundant amphophilic cytoplasm; (E) diffuse reactivity with NKX3.1, and (F) diffuse reactivity with synaptophysin