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. 2022 Jul 13;16:838692. doi: 10.3389/fnhum.2022.838692

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Copyright © 2022 Tran, DiGiacomo, Born, Georgiadis and Zeineh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Successive histologic images demonstrating consistent iron and microglia at the subiculum for 4 hippocampal specimens. Top row: representative magnetic resonance imaging virtual slices from each specimen. Successive rows: zoomed in histological sections. Single = 3,3′-diaminobenzidine (DAB)-iron (brown), double = DAB-iron (brown) plus CD163-microglia (blue), triple = DAB-iron (brown) plus CD163-microglia (blue) plus β-amyloid (red). Brightness, contrast, and color balance were adjusted homogeneously across each image to evenly emphasize iron deposits, microglia, β-amyloid deposits, and neurofibrillary tangles as well as neuropil threads. Figure from Zeineh et al. (2015).