Skip to main content
[Preprint]. 2022 Jul 19:2022.07.18.500565. [Version 1] doi: 10.1101/2022.07.18.500565

Table1.

Top 10 of the First stable mutation in sars-cov2, including nsp1 to nsp16

Locus mutant 1 mutant 2 mutant 3 mutant 4 mutant 5 mutant 6 mutant 7 mutant 8 mutant 9 mutant 10
nsp1 S(135)->R E(87)->D H(110)->Y R(24)->C R(124)->C V(28)->I S(100)->N E(37)->D K(120)->N P(62)->S
Rate 8% 0.8% 0.2% 0.2% 0.1% 0.1% 0.08% 0.08% 0.09% 0.08%
Country United States England United States Sudan Netherlands England France England
Continent North America Europe North America Africa Europe
Date 2020-04-03 2020-01-01 2020-04-01 2020-01-01
nsp2 T(85)->I K(81)->N P(129)->L L(550)->F G(339)->S A(419)->V A(318)->V E(587)->K R(27)->C V(485)->I
Rate 3.9% 2.1% 1.1% 0.9% 0.8% 0.5% 0.4% 0.3% 0.3% 0.3%
Country Netherlands DRC Russia England United States England Canada India United States
Continent Europe Africa Europe North America Europe North America Asia North America
Date 2020-01-01 2020-05-07 2020-01-01 2020-03-12 2020-01-01 2020-04-20 2020-01-01
nsp3 P(1228)->L P(1469)->S A(488)->S T(183)->I A(890)->D I(1412)->T A(1711)->V G(489)->S T(24)->I P(822)->L
Rate 50% 49.9% 49.4% 16.4% 16.3% 16.2% 14.2% 11.2% 11.2% 5.1%
Country England France England India Guangdong United States England
Continent Europe Asia North America Europe
Date 2020-01-01 2020-01-26 2020-04-03 2020-01-01
nsp4 T(492)->I V(167)->L L(438)->F L(264)->F T(327)->I A(446)->V V(94)->A A(146)->V F(17)->L A(92)->V
Rate 70.4% 37.9% 9.4% 9.7% 9.6% 4.1% 0.7% 0.5% 0.4% 0.5%
Country England Netherlands Germany Wuhan England Australia Wales England Northern Ireland
Continent Europe Asia Europe Oceania North America Europe
Date 2020-01-01 2019-12-30 2020-01-01 2020-08-07 2020-03-26 2020-01-01 2020-04-21
nsp5 P(132)->H K(90)->R L(89)->F T(169)->S P(108)->S A(260)->V G(15)->S K(88)->R T(21)->I P(96)->S
Rate 30.8% 1.6% 1.4% 0.5% 0.2% 0.2% 0.2% 0.1% 0.1% 0.06%
Country United States Japan Canada Ireland Netherlands United States France
Continent North America Asia North America Europe North America Europe
Date 2020-01-01 2021-01-01 2020-01-01 2020-03-01
nsp6 T(77)->A V(149)->A T(181)->I I(162)->V L(37)->F C(197)->F A(2)->V I(49)->V H(11)->Q Q(160)->R
Rate 71.1% 6.8% 5.5% 3.3% 2.9% 2.5% 1.1% 0.6% 0.4% 0.4%
Country France England United States New Zealand Lithuania Ecuador United States Italy Singapore
Continent Europe North America Oceania Europe South America North America Europe Asia
Date 2020-01-01 2020-06-24 2020-01-01 2020-04-18 2020-01-01 2020-04-11 2020-01-27
nsp7 L(71)->F S(25)->L L(56)->F D(77)->N M(75)->I M(3)->I S(26)->F T(81)->I Q(63)->H V(58)->I
Rate 0.2% 0.1% 0.1% 0.08% 0.09% 0.05% 0.06% 0.05% 0.02% 0.02%
Country England Austria India Netherlands Gibraltar Belgium England Colombia United States
Continent Europe Asia Europe South America North America
Date 2020-01-01 2020-03-01 2020-01-01 2020-05-12 2020-03-17
nsp8 Q(24)->R T(145)->I T(141)->M T(148)->I T(187)->I T(123)->I P(10)->S T(89)->I V(34)->F Q(198)->H
Rate 0.7% 0.6% 0.3% 0.1% 0.1% 0.1% 0.1% 0.08% 0.07 0.07%
Country England United States England United States England Netherlands England United States
Continent Europe North America Europe North America Europe North America
Date 2020-01-01 2020-03-05 2020-01-01
nsp9 T(35)->I I(65)->V R(39)->K L(42)->F M(101)->I T(24)->I Q(11)->H T(34)->I T(109)->I T(21)->I
Rate 0.5% 0.4% 0.4% 0.2% 0.2% 0.1% 0.1% 0.1% 0.1% 0.1%
Country United States England Austria United States England New Zealand Austria
Continent North America Europe North America Europe Oceania Europe
Date 2020-01-01 2020-04-05 2020-01-01 2020-04-14 2020-01-01
nsp10 T(102)->I T(12)->I R(134)->C A(104)->V A(32)->V T(51)->I T(111)->I P(84)->S T(101)->I I(55)->T
Rate 0.1% 0.1% 0.7% 0.1% 0.08% 0.08% 0.08% 0.04% 0.07% 0.06%
Country England Malaysia Ecuador Kazakhstan England India Senegal United States
Continent Europe Asia South America Asia Europe Asia Africa North America
Date 2020-01-01 2020-03-14 2020-01-01 2020-03-25 2020-01-01 2020-03-18
nsp11 S(6)->L A(4)->V A(2)->V F(11)->L A(12)->V S(1)->L Q(5)->R D(3)->G G(10)->R F(7)->L
Rate 0.1% 0.03% 0.02% 0.005% 0.003% 0.002% 0.001% 0.001% 1/20E-06 4/99e-06
Country Greece United States Italy United States Netherlands United States India Belgium
Continent Europe North America Europe North America Europe North America Asia Europe
Date 2020-01-01 2020-03-26 2020-04-09 2020-03-09 2020-03-27 2020-10-11 2020-05-05 2020-09-10 2021-01-29
nsp12 P(323)->L G(671)->S L(838)->I F(192)->V F(694)->Y P(227)->L Q(875)->R A(185)->S R(197)->Q V(776)->L
Rate 99.3% 42.8% 3% 2.5% 2% 1.8% 0.5% 0.4% 0.5% 0.4%
Country England Mexico United States England United States England United States England
Continent Europe North America Europe North America Europe North America Europe
Date 2020-01-01 2020-05-01 2020-06-23 2020-06-12 2020-01-01 2020-04-08 2020-01-01 2020-04-06 2020-01-01
nsp13 P(77)->L R(392)->C I(334)->V K(460)->R H(164)->Y E(341)->D A(296)->S E(261)->D D(260)->Y S(36)->P
Rate 42.6% 9.8% 3.1% 2.5% 1.8% 1.4% 1% 0.9% 0.6% 0.5%
Country Netherlands England Russia Netherlands England Senegal Hong Kong
Continent Europe Africa Asia
Date 2020-01-01 2020-02-22
nsp14 A(394)->V I(42)->V N(129)->D P(46)->L T(16)->I P(451)->S A(323)->S M(72)->I P(43)->L S(374)->F
Rate 35.1% 33.9% 1.2% 0.7% 0.7% 0.5% 0.4% 0.4% 0.3% 0.3%
Country Greece United States United States Netherlands England United States Gambia Russia Japan France
Continent Europe North America Europe North America Africa Europe Asia Europe
Date 2020-01-01 2020-03-01
msp15 T(112)->I P(205)->L A(80)->V K(259)->R P(262)->S H(234)->Y V(127)->F V(320)->L A(171)->V T(33)->I
Rate 8.9% 0.2% 0.3% 0.2% 0.2% 0.2% 0.2% 0.1% 0.1% 0.1%
Country England Netherlands Oman England France Sweden Niger England
Continent Europe Asia Europe Africa Europe
Date 2020-01-01 2020-04-25 2020-01-01 2020-03-05 2020-03-09 2020-01-01
nsp16 R(216)->C K(160)->R Q(238)->H P(215)->L T(35)->I D(179)->G R(287)->I P(236)->S P(134)->S T(140)->I
Rate 1.2% 1.3% 0.9% 0.2% 0.2% 0.2% 0.2% 0.1% 0.2% 0.1%
Country Gibraltar Wuhan Japan Norway Netherlands Saudi Arabia Japan France New Zealand Netherlands
Continent Europe Asia Europe Asia Europe Oceania Europe
Date 2020-01-01 2019-12-30 2020-01-01 2020-03-09 2020-01-01 2020-03-24 2020-01-01 2020-03-01 2020-01-01