FIG 5.

Impact of T cell-specific IL-17RA expression on the CD8⁺ T cell response during MHV68 infection. dLck Cre-positive and dLck Cre-negative mice were infected as for Fig. 2 with splenocytes, and peritoneal cells were analyzed at 16 days postinfection. (A and B) Frequency of CD8⁺ T cells, defined as CD3⁺ CD8⁺ cells, in the spleen and peritoneal cavity. (C and D) Frequency of MHV68-specific CD8⁺ T cells, defined as CD3⁺ CD8⁺ CD44⁺ Orf6 (MHC class I tetramer)⁺ cells, in the spleen and peritoneal cavity. (E and F) Frequency of IFN-γ-producing CD8⁺ T cells, defined as CD3⁺ CD8⁺ IFN-γ⁺ cells, following ex vivo restimulation with MHV68 immunodominant peptides in the spleen and peritoneal cavity. Data were pooled from 2 or 3 independent experiments, with each symbol representing an individual mouse. Means and standard errors of the means are shown. *, P < 0.05; **, P < 0.01.