Table 1.
Definitions of blood flow metrics extracted from studies based on ROIs
| Term | Definition | |
|---|---|---|
| CBF | Mean CBF overall | Mean flow in whole brain minus tumour |
| Max CBF overall | Area of maximal flow in whole brain minus tumour | |
| Mean CBF white matter overall - both sides | Mean flow in white matter ipsilateral and contralateral to tumour | |
| Max CBF white matter overall - both sides | Area of maximal flow in white matter ipsilateral and contralateral to tumour | |
| Mean CBF white matter ipsilateral | Mean flow in white matter ipsilateral to tumour | |
| Mean CBF white matter contralateral | Mean flow in white matter contralateral to tumour | |
| Max CBF white matter contralateral | Area of maximal flow in white matter contralateral to tumour | |
| Max CBF grey matter contralateral | Area of maximal flow in grey matter contralateral to tumour | |
| Perilesional flow | Mean perilesional flow | Mean flow in non-enhancing T2 or FLAIR hyperintensity |
| Max perilesional flow | Area of maximal flow in non-enhancing T2 or FLAIR hyperintensity | |
| Mean relative perilesional flow - white matter reference | Mean perilesional flow/mean flow in ipsilateral or contralateral white matter | |
| Max relative perilesional flow - white matter reference | Max peri-lesional flow/mean flow in ipsilateral or contralateral white matter | |
| TBF | Mean TBF | Mean flow in tumour |
| Max TBF | Area of maximal flow in tumour | |
| Mean rTBF - all reference ROIs | Mean TBF/any reference ROI | |
| Mean rTBF - white matter reference | Mean TBF/mean flow in ipsilateral or contralateral white matter | |
| Mean rTBF - mixed | Mean TBF/area that includes both white matter and grey matter e.g. whole brain, contralateral mirror ROI | |
| Mean rTBF - grey matter reference | Mean TBF/mean flow in ipsilateral or contralateral grey matter | |
| Mean rTBF - cerebellum reference | Mean TBF/mean flow in any area of the cerebellum | |
| Max rTBF - all reference ROIs | Max TBF/any reference ROI | |
| Max rTBF - mixed | Max TBF/area that includes both white matter and grey matter e.g. whole brain, contralateral mirror ROI | |
| Max rTBF - white matter reference | Max TBF/mean flow in ipsilateral or contralateral white matter | |
| Max rTBF - grey matter reference | Max TBF/mean flow in ipsilateral or contralateral grey matter | |
| Max rTBF - cerebellum reference | Max TBF/mean flow in any area of the cerebellum |
CBF, cerebral blood flow; ROI, region of interest; TBF, tumoral blood flow.
Relative values were study defined and not generated.